Each vial contains 1,000,000 IU of benzylpenicillin in the form of its sodium salt.
The mechanism of action of benzylpenicillin is based on the inhibition of bacterial cell wall synthesis during the bacterial growth phase. This occurs through the inhibition of penicillin-binding proteins (PBPs), such as transpeptidases. As a result, a bactericidal effect is produced.
Indications
Benzylpenicillin is used in adults, adolescents, children, neonates, and premature infants for the treatment of the following infections caused by pathogens susceptible to penicillin: skin and wound infections, diphtheria (in combination with antitoxin), community-acquired pneumonia (CAP), empyema, erysipelas, bacterial endocarditis, peritonitis, meningitis, brain abscesses, osteomyelitis, genital tract infections caused by fusobacteria.
Benzylpenicillin is also used in the treatment of the following specific infections: anthrax, tetanus, gas gangrene, listeriosis, pasteurellosis, rat-bite fever, fusospirochetosis, actinomycosis.
Benzylpenicillin is also used for the treatment of complications of gonorrhoea and syphilis (e.g. gonococcal endocarditis or arthritis, congenital syphilis). In the case of gonorrhoea, the susceptibility of the Neisseria gonorrhoeae isolate to penicillin must be documented. However, in uncomplicated cases, depot penicillins (long-acting preparations) should be preferred.
Benzylpenicillin is not indicated for the treatment of syphilis during pregnancy.
Benzylpenicillin is used from the second stage of Lyme disease onwards (meningopolyneuritis – Garin-Bujadoux-Bannwarth syndrome, acrodermatitis chronica atrophicans, Lyme arthritis, Lyme carditis) when oral penicillin treatment is no longer considered appropriate. When using benzylpenicillin, accepted clinical recommendations regarding the targeted and rational use of antibacterial agents should be taken into consideration.