Each capsule contains 150 mg of fluconazole.
Fluconazole is a triazole antifungal agent. Its primary mechanism of action is the inhibition of 14-alpha-lanosterol demethylation via fungal cytochrome P₄₅₀, thereby disrupting ergosterol biosynthesis.
Indications
- Cryptococcal meningitis
- Coccidioidomycosis
- Invasive candidiasis
- Mucosal candidiasis, including oropharyngeal and esophageal candidiasis, candiduria, and chronic mucocutaneous candidiasis
- Chronic oral atrophic candidiasis (denture sore) when dental hygiene or local treatment is inadequate
- Vaginal candidiasis, acute or recurrent, when local therapy is inappropriate
- Candidal balanitis when local therapy is inappropriate
- Dermatomycoses, including tinea capitis and cutaneous Candida infections, when systemic therapy is indicated
- Onychomycosis when other agents are inappropriate
Fluconazole is indicated in adults for the prophylaxis of:
- Relapse of cryptococcal meningitis in patients at high risk of relapse
- Recurrence of oropharyngeal or esophageal candidiasis in HIV-infected patients at high risk of relapse
- Reduction in the frequency of recurrent vaginal candidiasis (4 or more episodes per year)
- Prophylaxis of candidal infections in patients with prolonged neutropenia (e.g., patients with hematological malignancies receiving chemotherapy or patients undergoing Hematopoietic Stem Cell Transplantation)